Archive for the ‘Diabetes Research and News’ Category

Metformin (brand names: Fortamet, Glucophage, Glucophage XR, Glumetza), a widely prescribed drug for diabetes 2, may reduce the risk of breast cancer in some women, recently study said.

According to the research published in the Journal of Clinical Oncology, Metformin use in postmenopausal women with diabetes was associated with lower incidence of invasive breast cancer.

During the 12 years of follow-up, 3,273 cases of breast cancer were diagnosed. The researchers compared breast cancer risk in diabetic women on different diabetes medicines to breast cancer risk in non-diabetic women.

• Diabetic women treated with other medicines for diabetes had a slightly higher than average risk of breast cancer than women without diabetes
• Diabetic women treated with metformin had a 25% lower likelihood of developing breast cancer compared to women without diabetes

Other studies have suggested that diabetes drug Metformin may help lower the risk of prostate, pancreatic, liver and oral cancer, and a reducing incidence of a variety of cancers.

Metformin Side Effects
Metformin may have a dual effect on diabetes and cancer cells via an insulin mediated mechanism. It is well tolerated for most people but also has side effects. Here are a few to be aware of:

• Diarrhea
• Headache
• Indigestion
• Loss of appetite
• Weight loss or gain
• Nausea
• Stomach upset

Notify your doctor immediately if you experience any severe symptoms!

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Two new studies have been published stating that gastric bypass surgery may be a useful new tool in diabetes treatment. The results of the two studies show that the surgery drastically reduces the symptoms of diabetes, or in some patients, it disappears altogether. Doctors are unsure why exactly this surgery works so well for Type 2 diabetes sufferers, but some believe it is due to hormone changes. This surgery is only available for diabetic patients with a body mass index of 35 or higher.

A typical woman has a body mass index between 19 and 25. According to researchers on the study, one diabetic woman who underwent the surgery now only uses 10 milligrams of insulin per day; she was taking nine times that pre-surgery. Unfortunately gastric bypass surgery doesn’t have the same effect on Type 1 diabetics. This is due to their fundamental differences. Type 1 diabetes is caused by an autoimmune disorder, whereas type 2 is generally a complication of obesity. While the pounds melt off, so do the symptoms of diabetes.

Gastric bypass surgery uses a band to segregate the stomach into two pouches. The doctors then reattach the small intestine to the upper half of the stomach, which is now significantly smaller. Bariatric surgeons typically only perform this type of surgery on someone who is morbidly obese, which is a body mass index or 40 or more. They will also perform gastric bypass on a patient with a body mass index of 35, if they also have a ‘co-morbid condition’ such as diabetes.

If you are not currently accepted for this type of surgery, you will have to control your diabetes using long acting insulins such as Lantus or Levemir. We recommend that you buy anti-diabetes medications online, at a Canadian pharmacy. This will significantly reduce the financial burden caused by a long term disease such as diabetes.

To see the original release, click here.

White rice is joining white bread as a contributor to the development of diabetes. According to new research, a eating a significant amount of white rice may raise your risk of developing type 2 diabetes, especially in Asian populations. It is not just the white rice though. Researchers say that the high intake of white rice in Asian populations, combined with modern life’s more sedentary lifestyles, are what is leading to these results.

Researchers believe white rice is creating a high diabetes risk due to its high glycemic index; it has a significantly higher glycemic index than that of most other whole grains, due to its processing. The report also showed that this diabetes risk was also higher in women than in men. According to their calculations, Asians who ate a large amount of white rice were 55% more likely to develop type 2 diabetes than those who ate less. The researchers noted only a 27% higher risk in other racial populations.

Although four studies were done, other scientists are suggesting that a more controlled trial will need to be completed in order for this to be seriously taken into consideration when creating one’s diet.

A new device available in the UK will enable diabetics to manage their condition with a Smartphone.

Diabetes affects 2.9 million people in the UK and monitoring blood glucose levels is essential to the management of diabetes; Especially those with type – 1 diabetes, an auto immune disease that can lead to dangerous rises in blood sugar levels. High blood sugar levels can lead to serious complications including damage to the heart, kidney’s, nerves and eyes.

The new device called the iBGStar, allows sufferers to check their blood sugar levels at any time using their Smartphone; the hi-tech glucose monitor being sold out of Boots stores is about 1 inch long and attaches to the Apple iphone or ipod touch.

The device comes with a free Diabetes Manager App that makes it possible to store, track and analyse medical data. Software carries out the analysis and flashes the results onto the screen. It also allows users to follow changing trends and variations, and factors in information such as carbohydrate intake, insulin injections and exercise.

Dominic Littlewood, a TV presenter who is helping to promote the device and is a diabetes sufferer himself said “I lead a hectic lifestyle and so keeping an eye on my blood glucose levels is challenging. iBGStar gives me the reassurance of knowing that I can get accurate blood glucose results using my iPhone, which I carry around anyway.”
Sarah Johnson, from the type-1 diabetes research charity JDRF, said: “Good blood glucose control is vital to reducing the long-term effects of diabetes, but it can be difficult and demanding to achieve. As such, we welcome all developments in technology that can help people with type-1 and type-2 diabetes take control of their condition.”

Artificial pancreas

Clinical trials are currently being run for a treatment that may change the lives of diabetics. Instead of scheduled blood sugar checks, diabetics with an artificial pancreas can sleep through the whole night. The artificial pancreas is designed to digitally monitor a patients glucose levels and adjust them when the get too high or too low.

When it becomes main stream, the bionic pancreas will be about the size of a cell phone, but for clinical trials the patients are hooked up to laptops. The device uses algorithms to determine how much insulin is needed and at which time. There are two parts under the skin, one to detect the patients’ glucose levels, and the other to inject the appropriate amount of insulin, or if necessary, the bionic pancreas can also inject Glucagon, a medication designed to rapidly raise dangerously low blood sugar levels.

The trials are currently only for adults and children in hospitals. For safety reasons, they are constantly monitored. The researchers are hoping to have this product on the market in the coming years, with patients being fitted with their artificial pancreas, monitored, and then sent home, no longer having to worry about lancets, insulin injections or what/how much they are eating.

Until the artificial pancreas has passed many more obstacles and testing, diabetics will have to continue their medication and monitoring regimens. In order to make it slightly easier, doctors may recommend that you buy Januvia, or other medications for type 2 diabetes to help regulate your blood sugar. .

Statin Risks Article

The United States Food and Drug Administration has issued a new warning for statins this week. Statins, a group of drugs designed to lower cholesterol, include such popular medications as Lipitor, Zocor, and Crestor. These warnings also apply to combination statins, such as Advicor and Simcor.

After the results of multiple studies, the FDA has warned statins users about the risk of raised blood sugar levels, which may lead to a diagnosis of Type 2 diabetes. The FDA also warned about reports of statins causing memory loss and confusion. However, they also remind doctors and patients about statins’ proven ability to reduce the risk of heart attack. Although the risks associated with taking statins disappeared after the medications were no longer taken, it may cause more harm than good in regards to a patient’s cardiac health.

The FDA’s warning will now be added to the medication information on new shipments. For more information, see the original release here.

Need or necessity...

A new drug is currently being tested as a novel new way to control insulin production. The drug, which is currently in phase 2 clinical trials, is currently called TAK-875. The research, which was completed on 426 patients with type 2 diabetes, is being run by scientists out of the University of Michigan Health System. They published their results in this week’s The Lancet.

TAK-875 is a free fatty acid receptor activator. The reason this drug is different from others, such as Amaryl or Duetact, is that it works in a glucose-dependant manner. That means that it only begins functioning when there is a significant amount of extra glucose in the system, such as after a meal. TAK-785 will then help the body with insulin production. Previous medications that are reputed to help produce insulin in this way are working in the body all the time, which significantly raises the risk of hypoglycemia, a dangerous lowering of blood glucose levels.

TAK-785, when used over 12 weeks, resulted in significantly lower blood glucose levels than a placebo. It was also generally well tolerated, with very few negative side effects being reported. To conclude, the researchers stated “TAK-875 significantly improved glycaemic control in patients with type 2 diabetes with minimum risk of hypoglycemia. The results show that activation of FFAR1 is a viable therapeutic target for treatment of type 2 diabetes.”

In order to be brought to market, TAK-785 will have to complete more rigorous FDA testing as it goes through phase 3 clinical trials, which involves a significantly more populated randomized trial.

from Boots in the Oven

Processed meats have long been considered inferior to “real” cuts of meat, such as t-bone steaks, pork loins and chicken breasts. But how bad are they?

According to new study published by the American Journal of Clinical Nutrition, these processed meats may lead to diabetes. Diabetes, a disease in which the body can not properly regulate insulin, affects over ….Americans each year. Many of them have to buy Lantus or other long-acting insulin injections such as the newly released Bydureon.

In a study of 2000 Native American people from four different states, researchers discovered a correlation between high processed meat intake and the development of diabetes. Almost half of Native Americans will have developed diabetes by age 55. Researchers aimed to find a basis for these staggering statistics.

Processed meats are a hypothesized common denominator. With many Native Americans living in rural reserves, far from grocery stores, consumers often choose to buy foods with a longer shelf life. This leads to consumption of processed meats such as Spam, and other canned goods. Spam in particular is often seen on Native American lands as it is a government-subsidized food.

At the start of the study, none of the 2000 participants had diabetes. Five years later, with the average participants’ age being 40 years, 243 of those surveyed had developed diabetes. Five hundred of the original participants had reported consuming a significant amount of processed meats.

Though there is no clear link as to why processed meats are more likely to cause diabetes than unprocessed meats, scientists hypothesize this may be caused by the significantly higher sodium levels in “spam” meats.

from leafy

Although they are one of the most widely-prescribed medications in the United States, statins have recently been linked to a higher risk of diabetes. Statins are cholesterol-lowering drugs such as Lipitor and Crestor.

The study, which was published in Annals of Internal Medicine, reported that women who were using statins at the start of the seven year study were nearly 50 percent more likely to develop diabetes than their non-statin-using counterparts. However, researchers stated that the benefits of statins are often more important than the risk of diabetes.

Although the reasons why statins may be causing diabetes are unclear, researchers hypothesize that the effects statins are having on the body may cause it to make slightly more sugar than usual. Statins may also cause the patient to exercise slightly less than usual, both of which are potential first steps to diabetes.

But for those patients at risk of heart disease, the lead researcher on the study was adamant that statins’ benefits will greatly outweigh the risk of diabetes. In order to counteract any negative risks of statins, researchers say to increase your exercise, and be sure to frequently monitor your blood sugar.

“The conclusion still stands that overall, those people who’ve got existing heart disease or have had previous strokes, they still would get vast benefit from statins,” says Naveed Sattar, a University of Glasgow diabetes and metabolism researcher.

Novo Nordisk has announced to open a Type 1 Diabetes Research Center in Seattle, Washington.

The firm says the “unique concept” behind the new center is to “pursue a translational research approach characterized by combining basic research and early proof-of-concept trials under one umbrella”. Novo claims that it will provide “the necessary scientific foundation to move early-stage discovery projects rapidly from animal models into small clinical exploratory trials in type 1 diabetes”.

The center is expected to open this summer and will be staffed by 20 researchers. It will be located on the same premises as Novo’s inflammation research center in Seattle “in order to foster natural research synergies between the two sites”.

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